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Atrolysin C

Definition:

EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.24 Metalloendopeptidases > 3.4.24.42 atrolysin C
Atroxase is a non-hemorrhagic zinc metalloendopeptidase from the western diamondback rattlesnake (Crotalus atrox) venom that cleaves fibrinogen, in peptidase family M12. It cleaves His5-/-Leu, Ser9-/-His, His10-/-Leu, Ala14-/-Leu and Tyr16-/-Leu in the insulin B chain. In venom it disrupts blood coagulation. It features an M12-family zinc catalytic domain.

References:

[1]. Fox J.W., et al. Substrate specificities and inhibition of two hemorrhagic zinc proteases Ht-c and Ht-d from Crotalus atrox venom (1986), Eur. J. Biochem. , 156, 65-72.

[2]. Mori N., et al. Biochemical characterization of hemorrhagic toxins with fibrinogenase activity isolated from Crotalus ruber ruber venom (1987), Arch. Biochem. Biophys. , 253, 108-121.

[3]. Layfield H.J., et al. Repurposing cancer drugs batimastat and marimastat to inhibit the activity of a group I metalloprotease from the venom of the western diamondback rattlesnake, Crotalus atrox (2020), Toxins , 12, 309.

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