Bacillolysin
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.24 Metalloendopeptidases > 3.4.24.28 bacillolysin
Aureolysin is a zinc metalloenzyme from Staphylococcus aureus, earlier confused with staphylokinase (a non-enzymatic plasminogen activator). It cleaves the insulin B chain with specificity similar to thermolysin, preferring a hydrophobic P1' residue, and activates the glutamyl endopeptidase (EC 3.4.21.19) of S. aureus. In the pathogen it contributes to virulence and protease cascades. It features a thermolysin-like zinc catalytic fold.
Aureolysin is a zinc metalloenzyme from Staphylococcus aureus, earlier confused with staphylokinase (a non-enzymatic plasminogen activator). It cleaves the insulin B chain with specificity similar to thermolysin, preferring a hydrophobic P1' residue, and activates the glutamyl endopeptidase (EC 3.4.21.19) of S. aureus. In the pathogen it contributes to virulence and protease cascades. It features a thermolysin-like zinc catalytic fold.
References:
Biomedical Dictionary
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