Caldopentamine synthase
Definition:
EC Tree > 2 Transferases > 2.5 Transferring alkyl or aryl groups, other than methyl groups > 2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date) > 2.5.1.127 caldopentamine synthase
Caldopentamine synthase is an aminopropyltransferase characterized from the thermophilic archaeon Hyperthermus butylicus. It transfers an aminopropyl group from S-adenosyl 3-(methylsulfanyl)propylamine onto norspermine, releasing S-methyl-5'-thioadenosine and producing caldopentamine. It can also synthesize norspermine from norspermidine and thermospermine from spermidine, both with lower activity. The long-chain polyamines stabilize double-stranded DNA at high temperatures. Unlike EC 2.5.1.23 and EC 2.5.1.126, this enzyme shows no activity with propylamine.
Caldopentamine synthase is an aminopropyltransferase characterized from the thermophilic archaeon Hyperthermus butylicus. It transfers an aminopropyl group from S-adenosyl 3-(methylsulfanyl)propylamine onto norspermine, releasing S-methyl-5'-thioadenosine and producing caldopentamine. It can also synthesize norspermine from norspermidine and thermospermine from spermidine, both with lower activity. The long-chain polyamines stabilize double-stranded DNA at high temperatures. Unlike EC 2.5.1.23 and EC 2.5.1.126, this enzyme shows no activity with propylamine.
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