Calpain-3
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.22 Cysteine endopeptidases > 3.4.22.54 calpain-3
Calpain-3 is a Ca2+-dependent cysteine protease found in skeletal muscle and genetically linked to limb-girdle muscular dystrophy type 2A. It is activated by autoproteolytic cleavage of insertion sequence 1 (IS1), which allows substrates and inhibitors access to the active site; substrates include the enzyme itself and connectin/titin. It belongs to peptidase family C2 and has broad endopeptidase activity and specificity. In muscle it contributes to sarcomere remodeling and repair. It features a calpain catalytic core with distinctive IS1 and IS2 insertions.
Calpain-3 is a Ca2+-dependent cysteine protease found in skeletal muscle and genetically linked to limb-girdle muscular dystrophy type 2A. It is activated by autoproteolytic cleavage of insertion sequence 1 (IS1), which allows substrates and inhibitors access to the active site; substrates include the enzyme itself and connectin/titin. It belongs to peptidase family C2 and has broad endopeptidase activity and specificity. In muscle it contributes to sarcomere remodeling and repair. It features a calpain catalytic core with distinctive IS1 and IS2 insertions.
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