Calpain 8

Definition:

EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.22 Cysteine endopeptidases > 3.4.22.B28 calpain 8
Calpain 8 is a stomach-specific calpain-family cysteine protease found in viruses and cellular organisms, with broad endopeptidase specificity. It is highly expressed in gastric mucosal cells and contributes to mucosal homeostasis and protection against stress-induced injury. It features a classical calpain-like catalytic architecture expressed predominantly in the stomach.

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