Calpain 9

Definition:

EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.22 Cysteine endopeptidases > 3.4.22.B29 calpain 9
Calpain 9 is a gastrointestinal calpain-family cysteine protease found in viruses and cellular organisms, with broad endopeptidase specificity. It is expressed in stomach and esophagus and is frequently downregulated in gastric cancer. In the gastrointestinal tract it contributes to mucosal protection and epithelial homeostasis. It features a classical calpain-like catalytic fold.

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