Calpain
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.22 Cysteine endopeptidases > 3.4.22.17 calpain
Calpain is a Ca2+-dependent intracellular cysteine protease that reversibly modulates protein function through limited, site-specific cleavage rather than bulk degradation. It participates in cytoskeletal remodeling, cell-cycle progression, apoptosis signaling and membrane-cytoskeleton attachment. In organisms it contributes to muscle plasticity, cell motility and Ca2+-triggered signaling. It features a cysteine-protease catalytic domain, a Ca2+-binding EF-hand regulatory domain and a calmodulin-like small subunit.
Calpain is a Ca2+-dependent intracellular cysteine protease that reversibly modulates protein function through limited, site-specific cleavage rather than bulk degradation. It participates in cytoskeletal remodeling, cell-cycle progression, apoptosis signaling and membrane-cytoskeleton attachment. In organisms it contributes to muscle plasticity, cell motility and Ca2+-triggered signaling. It features a cysteine-protease catalytic domain, a Ca2+-binding EF-hand regulatory domain and a calmodulin-like small subunit.
Biomedical Dictionary
The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.
Molarity Calculator
Dilution Calculator
