Capreomycidine synthase
Definition:
EC Tree > 4 Lyases > 4.2 Carbon-oxygen lyases > 4.2.1 Hydro-lyases > 4.2.1.145 capreomycidine synthase
Capreomycidine synthase is a pyridoxal-phosphate-dependent cyclase in the biosynthesis of the cyclic pentapeptide antibiotic viomycin. It dehydrates (2S,3S)-3-hydroxyarginine into (2S,3R)-capreomycidine and water, forming the capreomycidine residue characteristic of viomycin and capreomycin. It appears in viruses and cellular organisms. Structurally it is a PLP-dependent arginine cyclase.
Capreomycidine synthase is a pyridoxal-phosphate-dependent cyclase in the biosynthesis of the cyclic pentapeptide antibiotic viomycin. It dehydrates (2S,3S)-3-hydroxyarginine into (2S,3R)-capreomycidine and water, forming the capreomycidine residue characteristic of viomycin and capreomycin. It appears in viruses and cellular organisms. Structurally it is a PLP-dependent arginine cyclase.
References:
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