Carnosine synthase
Definition:
EC Tree > 6 Ligases > 6.3 Forming carbon-nitrogen bonds > 6.3.2 Acid—amino-acid ligases (peptide synthases) > 6.3.2.11 carnosine synthase
Carnosine synthase (CARNS1) forms ADP rather than AMP: ATP plus L-histidine plus β-alanine yields ADP plus phosphate plus carnosine. Carnosine is a dipeptide present at high concentration in skeletal muscle and olfactory bulb of vertebrates (and in some invertebrate skeletal muscle); the enzyme can also form homocarnosine from 4-aminobutanoate plus L-histidine. Structurally it is a member of the ATP-grasp fold.
Carnosine synthase (CARNS1) forms ADP rather than AMP: ATP plus L-histidine plus β-alanine yields ADP plus phosphate plus carnosine. Carnosine is a dipeptide present at high concentration in skeletal muscle and olfactory bulb of vertebrates (and in some invertebrate skeletal muscle); the enzyme can also form homocarnosine from 4-aminobutanoate plus L-histidine. Structurally it is a member of the ATP-grasp fold.
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