Caspase-2
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.22 Cysteine endopeptidases > 3.4.22.55 caspase-2
Caspase-2 is an initiator caspase, together with caspase-8 (EC 3.4.22.61), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63). It contains a caspase-recruitment domain (CARD) in its N-terminal prodomain that participates in procaspase activation. Two antagonistic forms exist: caspase-2L induces programmed cell death, while caspase-2S suppresses it. It has a strict requirement for Asp at P1, with Asp316 essential for activity, and a preferred cleavage sequence Val-Asp-Val-Ala-Asp-/-. In cells it participates in stress-induced apoptosis and the DNA-damage response. It features a CARD domain fused to a p19/p10 catalytic heterodimer.
Caspase-2 is an initiator caspase, together with caspase-8 (EC 3.4.22.61), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63). It contains a caspase-recruitment domain (CARD) in its N-terminal prodomain that participates in procaspase activation. Two antagonistic forms exist: caspase-2L induces programmed cell death, while caspase-2S suppresses it. It has a strict requirement for Asp at P1, with Asp316 essential for activity, and a preferred cleavage sequence Val-Asp-Val-Ala-Asp-/-. In cells it participates in stress-induced apoptosis and the DNA-damage response. It features a CARD domain fused to a p19/p10 catalytic heterodimer.
Biomedical Dictionary
The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.
Molarity Calculator
Dilution Calculator
