Caspase-4
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.22 Cysteine endopeptidases > 3.4.22.57 caspase-4
Caspase-4 is an inflammatory caspase, part of the family that also includes human caspase-1 (EC 3.4.22.36) and caspase-5 (EC 3.4.22.58) and murine caspase-11, -12, -13 and -14. It contains a CARD in its N-terminal prodomain for procaspase activation, and can cleave itself and the p30 fragment of gasdermin D. It has a strict requirement for Asp at P1, with a preferred cleavage sequence Tyr-Val-Ala-Asp-/- and also cleaving at Asp-Glu-Val-Asp-/-. In cells it senses cytosolic lipopolysaccharide and drives pyroptosis. It features a CARD-p20-p10 architecture.
Caspase-4 is an inflammatory caspase, part of the family that also includes human caspase-1 (EC 3.4.22.36) and caspase-5 (EC 3.4.22.58) and murine caspase-11, -12, -13 and -14. It contains a CARD in its N-terminal prodomain for procaspase activation, and can cleave itself and the p30 fragment of gasdermin D. It has a strict requirement for Asp at P1, with a preferred cleavage sequence Tyr-Val-Ala-Asp-/- and also cleaving at Asp-Glu-Val-Asp-/-. In cells it senses cytosolic lipopolysaccharide and drives pyroptosis. It features a CARD-p20-p10 architecture.
References:
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[1]. Talanian R.V., et al. Substrate specificities of caspase family proteases (1997), J. Biol. Chem. , 272, 9677-9682. [Content Brief]
[2]. Kamens J., et al. Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases (1995), J. Biol. Chem. , 270, 15250-15256. [Content Brief]
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