Caspase-5
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.22 Cysteine endopeptidases > 3.4.22.58 caspase-5
Caspase-5 is an inflammatory caspase, part of the family that also includes human caspase-1 (EC 3.4.22.36) and caspase-4 (EC 3.4.22.57) and murine caspase-11, -12, -13 and -14. It contains a CARD in its N-terminal prodomain for procaspase activation, and can cleave itself and the p30 fragment of gasdermin D. It has a strict requirement for Asp at P1, with a preferred cleavage sequence Tyr-Val-Ala-Asp-/- and also cleaving at Asp-Glu-Val-Asp-/-. In cells it acts as a cytosolic lipopolysaccharide sensor and drives pyroptosis in concert with caspase-4. It features a CARD-p20-p10 architecture.
Caspase-5 is an inflammatory caspase, part of the family that also includes human caspase-1 (EC 3.4.22.36) and caspase-4 (EC 3.4.22.57) and murine caspase-11, -12, -13 and -14. It contains a CARD in its N-terminal prodomain for procaspase activation, and can cleave itself and the p30 fragment of gasdermin D. It has a strict requirement for Asp at P1, with a preferred cleavage sequence Tyr-Val-Ala-Asp-/- and also cleaving at Asp-Glu-Val-Asp-/-. In cells it acts as a cytosolic lipopolysaccharide sensor and drives pyroptosis in concert with caspase-4. It features a CARD-p20-p10 architecture.
References:
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[1]. Kamada S., et al. Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases (1997), Cell Death Differ. , 4, 473-478. [Content Brief]
[3]. Mintzer R., et al. A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin a/c (2012), PLoS ONE , 7, e30376. [Content Brief]
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