Caspase-9
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.22 Cysteine endopeptidases > 3.4.22.62 caspase-9
Caspase-9 is an initiator caspase, together with caspase-2 (EC 3.4.22.55), caspase-8 (EC 3.4.22.61) and caspase-10 (EC 3.4.22.63). It contains a CARD in its N-terminal prodomain for procaspase activation on the apoptosome. An alternatively spliced variant, caspase-9S, inhibits apoptosis. It has a strict requirement for Asp at P1, a marked preference for His at P2, and a preferred cleavage sequence Leu-Gly-His-Asp-/-Xaa. In cells it executes the mitochondrial, intrinsic apoptosis pathway. It features a CARD-p20-p10 architecture activated by APAF-1 apoptosome assembly.
Caspase-9 is an initiator caspase, together with caspase-2 (EC 3.4.22.55), caspase-8 (EC 3.4.22.61) and caspase-10 (EC 3.4.22.63). It contains a CARD in its N-terminal prodomain for procaspase activation on the apoptosome. An alternatively spliced variant, caspase-9S, inhibits apoptosis. It has a strict requirement for Asp at P1, a marked preference for His at P2, and a preferred cleavage sequence Leu-Gly-His-Asp-/-Xaa. In cells it executes the mitochondrial, intrinsic apoptosis pathway. It features a CARD-p20-p10 architecture activated by APAF-1 apoptosome assembly.
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