Cathepsin E
Definition:
Cathepsin E is a non-lysosomal aspartic endopeptidase found in stomach, spleen and erythrocyte membrane. Pro-cathepsin E is an 86-kDa disulfide-linked dimer; activation or reduction produces the monomer. It belongs to peptidase family A1. Its specificity is similar to cathepsin D but slightly broader. In immune and gastric cells it contributes to antigen processing and peptide generation. It features a pepsin-like aspartic-protease fold.
References:
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[1]. Yasuda Y., et al. A new selective substrate for cathepsin E based on the cleavage site sequence of alpha2-macroglobulin (2005), Biol. Chem. , 386, 299-305. [Content Brief]
[2]. Kwan J.C., et al. Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation (2009), J. Med. Chem. , 52, 5732-5747. [Content Brief]
[3]. MacKay V.L., et al. ) Plenum Press, New York , , 161-172.
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