Cathepsin K
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.22 Cysteine endopeptidases > 3.4.22.38 cathepsin K
Cathepsin K is a lysosomal cysteine endopeptidase in peptidase family C1 (papain family), prominently expressed in mammalian osteoclasts and believed to play a central role in bone resorption. It has broad proteolytic activity; with small-molecule substrates and inhibitors, the major determinant of specificity is P2, preferably Leu, Met > Phe, and not Arg. In the osteoclast it degrades type I collagen and other bone matrix proteins. It is a major drug target for osteoporosis. It features a papain-like fold with an unusual collagenase-specific occluding loop.
Cathepsin K is a lysosomal cysteine endopeptidase in peptidase family C1 (papain family), prominently expressed in mammalian osteoclasts and believed to play a central role in bone resorption. It has broad proteolytic activity; with small-molecule substrates and inhibitors, the major determinant of specificity is P2, preferably Leu, Met > Phe, and not Arg. In the osteoclast it degrades type I collagen and other bone matrix proteins. It is a major drug target for osteoporosis. It features a papain-like fold with an unusual collagenase-specific occluding loop.
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