Cathepsin V
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.22 Cysteine endopeptidases > 3.4.22.43 cathepsin V
Cathepsin V is a human lysosomal cysteine endopeptidase of family C1 (papain family), maximally active at pH 5.7 and unstable at neutral pH. It is inhibited by compound E-64, leupeptin and chicken cystatin, and shows expression restricted to thymus, testis, corneal epithelium and some colon and breast carcinomas, with the human gene at locus 9q22.2. The recombinant enzyme hydrolyzes proteins such as serum albumin and collagen, and synthetic substrates in the order Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec. In tissues it contributes to thymic antigen selection and corneal collagen turnover. It features a papain-like fold with a distinctive P2 specificity.
Cathepsin V is a human lysosomal cysteine endopeptidase of family C1 (papain family), maximally active at pH 5.7 and unstable at neutral pH. It is inhibited by compound E-64, leupeptin and chicken cystatin, and shows expression restricted to thymus, testis, corneal epithelium and some colon and breast carcinomas, with the human gene at locus 9q22.2. The recombinant enzyme hydrolyzes proteins such as serum albumin and collagen, and synthetic substrates in the order Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec. In tissues it contributes to thymic antigen selection and corneal collagen turnover. It features a papain-like fold with a distinctive P2 specificity.
References:
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