Cembrene A synthase
Definition:
EC Tree > 4 Lyases > 4.2 Carbon-oxygen lyases > 4.2.3 Acting on phosphates > 4.2.3.150 cembrene A synthase
Cembrene A synthase is a Mg2+-dependent trifunctional [4Fe-4S]-containing diterpene cyclase from Streptomyces sp. SANK 60404. It cyclizes geranylgeranyl diphosphate into (R)-cembrene A and diphosphate, also producing (R)-nephthenol and (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol (see EC 4.2.3.149 and EC 4.2.3.151). Structurally it is a cembranoid cyclase.
Cembrene A synthase is a Mg2+-dependent trifunctional [4Fe-4S]-containing diterpene cyclase from Streptomyces sp. SANK 60404. It cyclizes geranylgeranyl diphosphate into (R)-cembrene A and diphosphate, also producing (R)-nephthenol and (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol (see EC 4.2.3.149 and EC 4.2.3.151). Structurally it is a cembranoid cyclase.
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