Ceramidase
Definition:
EC Tree > 3 Hydrolases > 3.5 Acting on carbon-nitrogen bonds, other than peptide bonds > 3.5.1 In linear amides > 3.5.1.23 ceramidase
Choloylglycine hydrolase is a gut bacterial hydrolase found in bacteria, eukaryotes and archaea, also acting on the 3alpha,12alpha-dihydroxy derivative and choloyl-taurine. It hydrolyzes glycocholate into cholate and glycine. In the gut microbiome it deconjugates bile acids. It features a cholylglycine hydrolase fold.
Choloylglycine hydrolase is a gut bacterial hydrolase found in bacteria, eukaryotes and archaea, also acting on the 3alpha,12alpha-dihydroxy derivative and choloyl-taurine. It hydrolyzes glycocholate into cholate and glycine. In the gut microbiome it deconjugates bile acids. It features a cholylglycine hydrolase fold.
References:
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[1]. El Bawab S., et al. Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase (2001), J. Biol. Chem. , 276, 16758-16766. [Content Brief]
[2]. Galadari S., et al. Identification of a novel amidase motif in neutral ceramidase (2006), Biochem. J. , 393, 687-695. [Content Brief]
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