Ceramide kinase
Definition:
EC Tree > 2 Transferases > 2.7 Transferring phosphorus-containing groups > 2.7.1 Phosphotransferases with an alcohol group as acceptor > 2.7.1.138 ceramide kinase
Ceramide kinase is a sphingolipid-signaling kinase. It phosphorylates ceramide on the 1-hydroxyl, releasing ADP and ceramide 1-phosphate, a bioactive sphingolipid that promotes cell survival, proliferation and inflammation. It is enriched in the plasma membrane and Golgi, and is distinct from the ceramide-sphingomyelin cycle. It occurs in viruses and cellular organisms.
Ceramide kinase is a sphingolipid-signaling kinase. It phosphorylates ceramide on the 1-hydroxyl, releasing ADP and ceramide 1-phosphate, a bioactive sphingolipid that promotes cell survival, proliferation and inflammation. It is enriched in the plasma membrane and Golgi, and is distinct from the ceramide-sphingomyelin cycle. It occurs in viruses and cellular organisms.
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