Cholate-CoA ligase
Definition:
EC Tree > 6 Ligases > 6.2 Forming carbon-sulfur bonds > 6.2.1 Acid-thiol ligases > 6.2.1.7 cholate-CoA ligase
Cholate-CoA ligase requires Mg2+. The mammalian membrane-bound enzyme catalyzes the first step in the conjugation of bile acids with amino acids, converting bile acids to their acyl-CoA thioesters; chenodeoxycholate, deoxycholate, lithocholate and trihydroxycoprostanoate also act as substrates. The soluble bacterial enzyme participates in anaerobic bile-acid 7α-dehydroxylation. Structurally it is a bile-acid CoA ligase (BAAT).
Cholate-CoA ligase requires Mg2+. The mammalian membrane-bound enzyme catalyzes the first step in the conjugation of bile acids with amino acids, converting bile acids to their acyl-CoA thioesters; chenodeoxycholate, deoxycholate, lithocholate and trihydroxycoprostanoate also act as substrates. The soluble bacterial enzyme participates in anaerobic bile-acid 7α-dehydroxylation. Structurally it is a bile-acid CoA ligase (BAAT).
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