Coagulation factor Xa
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.21 Serine endopeptidases > 3.4.21.6 coagulation factor Xa
Coagulation factor Xa is a blood-coagulation serine protease in family S1 formed from proenzyme factor X by limited proteolysis; factor X is a glycoprotein of heavy and light chains generated from a precursor by excision of the tripeptide RKR and held by disulfide bonds, and activated Xa converts prothrombin to thrombin in the presence of factor Va, Ca2+ and phospholipids (scutelarin EC 3.4.21.60 has similar specificity but does not require Va); it selectively cleaves Arg-Thr and then Arg-Ile bonds in prothrombin to form thrombin. By generating thrombin it is the key enzyme of the common coagulation pathway. It appears in viruses and cellular organisms.
Coagulation factor Xa is a blood-coagulation serine protease in family S1 formed from proenzyme factor X by limited proteolysis; factor X is a glycoprotein of heavy and light chains generated from a precursor by excision of the tripeptide RKR and held by disulfide bonds, and activated Xa converts prothrombin to thrombin in the presence of factor Va, Ca2+ and phospholipids (scutelarin EC 3.4.21.60 has similar specificity but does not require Va); it selectively cleaves Arg-Thr and then Arg-Ile bonds in prothrombin to form thrombin. By generating thrombin it is the key enzyme of the common coagulation pathway. It appears in viruses and cellular organisms.
References:
Biomedical Dictionary
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