Coagulation factor XIa
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.21 Serine endopeptidases > 3.4.21.27 coagulation factor XIa
Coagulation factor XIa is a serine protease in family S1 and one of the gamma-carboxyglutamic-acid-containing coagulation factors; proenzyme factor XI is activated by factor XIIa, and it selectively cleaves Arg-Ala and Arg-Val bonds in factor IX to form factor IXa. By propagating the contact-activation coagulation cascade it drives blood coagulation. It appears in viruses and cellular organisms.
Coagulation factor XIa is a serine protease in family S1 and one of the gamma-carboxyglutamic-acid-containing coagulation factors; proenzyme factor XI is activated by factor XIIa, and it selectively cleaves Arg-Ala and Arg-Val bonds in factor IX to form factor IXa. By propagating the contact-activation coagulation cascade it drives blood coagulation. It appears in viruses and cellular organisms.
References:
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