Coagulation factor XIIa
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.21 Serine endopeptidases > 3.4.21.38 coagulation factor XIIa
Coagulation factor XIIa (Hageman factor) is a contact-activation serine protease in family S1 formed from factor XII by plasma kallikrein or factor XIIa, which also activates plasminogen and plasma prokallikrein; it selectively cleaves Arg-Ile bonds in factor VII to form VIIa and in factor XI to form XIa. By initiating the contact-activation cascade it triggers coagulation, inflammation and bradykinin generation. It is taxonomically restricted to Tetrapoda.
Coagulation factor XIIa (Hageman factor) is a contact-activation serine protease in family S1 formed from factor XII by plasma kallikrein or factor XIIa, which also activates plasminogen and plasma prokallikrein; it selectively cleaves Arg-Ile bonds in factor VII to form VIIa and in factor XI to form XIa. By initiating the contact-activation cascade it triggers coagulation, inflammation and bradykinin generation. It is taxonomically restricted to Tetrapoda.
References:
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[1]. Cho K., et al. Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates (1984), Biochemistry , 23, 644-650. [Content Brief]
[2]. MacQuarrie J.L., et al. Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation (2011), Blood , 117, 4134-4141. [Content Brief]
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