Cobaltochelatase
Definition:
EC Tree > 6 Ligases > 6.6 Forming nitrogen-metal bonds > 6.6.1 Forming coordination complexes > 6.6.1.2 cobaltochelatase
Cobaltochelatase inserts Co2+ into hydrogenobyrinate a,c-diamide, the penultimate step of the aerobic (late cobalt-insertion) cobalamin pathway. It is a heterotrimeric ATP-dependent type I chelatase comprising CobN and the CobST two-polypeptide subunit pair (as in Pseudomonas denitrificans). Hydrogenobyrinate is a very poor substrate. Structurally it is an ATP-dependent cobalamin chelatase.
Cobaltochelatase inserts Co2+ into hydrogenobyrinate a,c-diamide, the penultimate step of the aerobic (late cobalt-insertion) cobalamin pathway. It is a heterotrimeric ATP-dependent type I chelatase comprising CobN and the CobST two-polypeptide subunit pair (as in Pseudomonas denitrificans). Hydrogenobyrinate is a very poor substrate. Structurally it is an ATP-dependent cobalamin chelatase.
References:
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