Corrinoid adenosyltransferase
Definition:
EC Tree > 2 Transferases > 2.5 Transferring alkyl or aryl groups, other than methyl groups > 2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date) > 2.5.1.17 corrinoid adenosyltransferase
Corrinoid adenosyltransferase is the CobA/PduO-type adenosyltransferase that converts cobalamin and related corrinoids into their Co-adenosyl active cofactors. In three steps it reduces Co(III) to Co(II), binds the corrinoid and raises the Co(II)/Co(I) potential by ~250 mV, accepts a second electron to Co(I), and the Co(I) attacks ATP to transfer 5'-deoxyadenosyl and oxidize cobalt back to Co(III), releasing triphosphate. In Salmonella enterica the cobA housekeeping enzyme acts in both de novo biosynthesis and salvage, and pduO in propanediol utilization; the mammalian enzyme is PduO-type and can act on cob(II)inamide. It occurs in Bacteria, Eukaryota and Archaea.
Corrinoid adenosyltransferase is the CobA/PduO-type adenosyltransferase that converts cobalamin and related corrinoids into their Co-adenosyl active cofactors. In three steps it reduces Co(III) to Co(II), binds the corrinoid and raises the Co(II)/Co(I) potential by ~250 mV, accepts a second electron to Co(I), and the Co(I) attacks ATP to transfer 5'-deoxyadenosyl and oxidize cobalt back to Co(III), releasing triphosphate. In Salmonella enterica the cobA housekeeping enzyme acts in both de novo biosynthesis and salvage, and pduO in propanediol utilization; the mammalian enzyme is PduO-type and can act on cob(II)inamide. It occurs in Bacteria, Eukaryota and Archaea.
References:
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