CPB protease
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.22 Cysteine endopeptidases > 3.4.22.B5 CPB protease
CPB protease is a cathepsin-B-like cysteine endopeptidase found in viruses and cellular organisms. It cleaves the Arg-Phe bond well; the best substrate ortho-aminobenzoyl-KLR-/-FSKQ-(N-(2,4-dinitrophenyl)ethylenediamine) is also hydrolyzed by cathepsin L, but the corresponding inhibitor has low affinity to cathepsin L, making the parasite enzyme druggable. In parasites it contributes to host protein degradation and virulence. It features a papain-like catalytic fold.
CPB protease is a cathepsin-B-like cysteine endopeptidase found in viruses and cellular organisms. It cleaves the Arg-Phe bond well; the best substrate ortho-aminobenzoyl-KLR-/-FSKQ-(N-(2,4-dinitrophenyl)ethylenediamine) is also hydrolyzed by cathepsin L, but the corresponding inhibitor has low affinity to cathepsin L, making the parasite enzyme druggable. In parasites it contributes to host protein degradation and virulence. It features a papain-like catalytic fold.
References:
Biomedical Dictionary
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