Cyclic GMP-AMP synthase
Definition:
EC Tree > 2 Transferases > 2.7 Transferring phosphorus-containing groups > 2.7.7 Nucleotidyltransferases > 2.7.7.86 cyclic GMP-AMP synthase
Cyclic GMP-AMP synthase (cGAS) is the mammalian cytosolic DNA sensor. It condenses ATP and GTP into cyclic Gp(2'-5')Ap(3'-5') (via a pppG(2'-5')A intermediate), releasing two diphosphate; the cGAMP second messenger binds STING and triggers type-I interferon and cytokine production. It occurs in viruses and cellular organisms.
Cyclic GMP-AMP synthase (cGAS) is the mammalian cytosolic DNA sensor. It condenses ATP and GTP into cyclic Gp(2'-5')Ap(3'-5') (via a pppG(2'-5')A intermediate), releasing two diphosphate; the cGAMP second messenger binds STING and triggers type-I interferon and cytokine production. It occurs in viruses and cellular organisms.
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