Cyclin-dependent kinase
Definition:
EC Tree > 2 Transferases > 2.7 Transferring phosphorus-containing groups > 2.7.11 Protein-serine/threonine kinases > 2.7.11.22 cyclin-dependent kinase
Cyclin-dependent kinase (CDK) is the cell-cycle-engine Ser/Thr kinase. It is activated only upon binding a cyclin regulatory subunit; sequential synthesis and destruction of cyclins activates/inactivates CDKs, which phosphorylate retinoblastoma, lamins and other cell-cycle substrates, releasing ADP. It is the primary cell-cycle regulator in eukaryotes. It occurs in viruses and cellular organisms.
Cyclin-dependent kinase (CDK) is the cell-cycle-engine Ser/Thr kinase. It is activated only upon binding a cyclin regulatory subunit; sequential synthesis and destruction of cyclins activates/inactivates CDKs, which phosphorylate retinoblastoma, lamins and other cell-cycle substrates, releasing ADP. It is the primary cell-cycle regulator in eukaryotes. It occurs in viruses and cellular organisms.
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