Cyclohexanone monooxygenase
Definition:
EC Tree > 1 Oxidoreductases > 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen > 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor > 1.14.13.22 cyclohexanone monooxygenase
Cyclohexanone monooxygenase is an FAD-containing Baeyer-Villiger flavoprotein; the nucleophile attacking the carbonyl is a peroxyflavin generated from enzyme-bound flavin, NAD(P)H and O2. It catalyzes a wide range of oxidations, converting cyclohexanone with NADPH and O2 into ε-caprolactone, releasing H2O and NADP+.
Cyclohexanone monooxygenase is an FAD-containing Baeyer-Villiger flavoprotein; the nucleophile attacking the carbonyl is a peroxyflavin generated from enzyme-bound flavin, NAD(P)H and O2. It catalyzes a wide range of oxidations, converting cyclohexanone with NADPH and O2 into ε-caprolactone, releasing H2O and NADP+.
References:
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