D-lactate dehydratase
Definition:
EC Tree > 4 Lyases > 4.2 Carbon-oxygen lyases > 4.2.1 Hydro-lyases > 4.2.1.130 D-lactate dehydratase
D-lactate dehydratase is a GSH-independent dehydratase from the fungi Candida albicans and Schizosaccharomyces pombe that converts 2-oxopropanal (methylglyoxal) into (R)-lactate in a single step. The other known route is the two-step GSH-dependent pathway of EC 4.4.1.5 (lactoylglutathione lyase) plus EC 3.1.2.6 (hydroxyacylglutathione hydrolase). Structurally it is a methylglyoxal reductase/dehydratase.
D-lactate dehydratase is a GSH-independent dehydratase from the fungi Candida albicans and Schizosaccharomyces pombe that converts 2-oxopropanal (methylglyoxal) into (R)-lactate in a single step. The other known route is the two-step GSH-dependent pathway of EC 4.4.1.5 (lactoylglutathione lyase) plus EC 3.1.2.6 (hydroxyacylglutathione hydrolase). Structurally it is a methylglyoxal reductase/dehydratase.
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