Dipeptidase E
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.13 Dipeptidases > 3.4.13.21 dipeptidase E
Dipeptidase E is a serine peptidase in family S51 that hydrolyses dipeptides Asp-Xaa; a free carboxy group is not absolutely required since Asp-Phe-NH2 and Asp-Phe-OMe are hydrolysed somewhat more slowly than free-C-terminus dipeptides, no peptide larger than a C-blocked dipeptide is a substrate, Asp-NH-Np is a convenient assay substrate, the enzyme is most active near pH 7.0 and is not inhibited by diisopropyl fluorophosphate or phenylmethanesulfonyl fluoride; it does not act on peptides with N-terminal Glu, Asn or Gln and does not cleave isoaspartyl peptides. By digesting Asp-Xaa dipeptides it participates in cytosolic peptide catabolism. It is distributed across Eukaryota and Bacteria.
Dipeptidase E is a serine peptidase in family S51 that hydrolyses dipeptides Asp-Xaa; a free carboxy group is not absolutely required since Asp-Phe-NH2 and Asp-Phe-OMe are hydrolysed somewhat more slowly than free-C-terminus dipeptides, no peptide larger than a C-blocked dipeptide is a substrate, Asp-NH-Np is a convenient assay substrate, the enzyme is most active near pH 7.0 and is not inhibited by diisopropyl fluorophosphate or phenylmethanesulfonyl fluoride; it does not act on peptides with N-terminal Glu, Asn or Gln and does not cleave isoaspartyl peptides. By digesting Asp-Xaa dipeptides it participates in cytosolic peptide catabolism. It is distributed across Eukaryota and Bacteria.
Biomedical Dictionary
The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.
Molarity Calculator
Dilution Calculator
