Diphthine methyl ester synthase
Definition:
EC Tree > 2 Transferases > 2.1 Transferring one-carbon groups > 2.1.1 Methyltransferases > 2.1.1.314 diphthine methyl ester synthase
Diphthine methyl ester synthase is the eukaryotic enzyme that installs four methyl groups on the diphthine precursor of elongation factor 2, producing diphthine methyl ester; unlike the archaeal EC 2.1.1.98 it carries out four rather than three methylations at the conserved histidine (His715 in mammals, His699 in yeast).
Diphthine methyl ester synthase is the eukaryotic enzyme that installs four methyl groups on the diphthine precursor of elongation factor 2, producing diphthine methyl ester; unlike the archaeal EC 2.1.1.98 it carries out four rather than three methylations at the conserved histidine (His715 in mammals, His699 in yeast).
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