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DNA primase AEP

Definition:

EC Tree > 2 Transferases > 2.7 Transferring phosphorus-containing groups > 2.7.7 Nucleotidyltransferases > 2.7.7.102 DNA primase AEP
DNA primase AEP is the eukaryotic/archaeal archaeo-eukaryotic primase. Using ssDNA template and NTPs or dNTPs, it synthesizes short RNA or DNA primers, releasing (n-1) diphosphate, that are extended by DNA polymerase. Expected in Eukaryota and Archaea.

References:

[1]. Bocquier A., et al. Archaeal primase Bridging the gap between RNA and DNA polymerases (2001), Curr. Biol. , 11, 452-456.

[2]. Gill S., et al. A highly divergent archaeo-eukaryotic primase from the Thermococcus nautilus plasmid, pTN2 (2014), Nucleic Acids Res. , 42, 3707-3719.

[3]. Taylor Z.W., et al. Manganese-induced substrate promiscuity in the reaction catalyzed by phosphoglutamine cytidylyltransferase from Campylobacter jejuni (2019), Biochemistry , 58, 2144-2151 .

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