EM-2

Definition:

EM-2 is a human cancer cell line derived from Bone marrow and associated with Childhood chronic myelogenous leukemia, BCR-ABL1 positive and Chronic myeloid leukemia. Its continuous tumor-cell growth supports reproducible mechanistic and pharmacological experiments. EM-2 is used as an in vitro model of Childhood chronic myelogenous leukemia, BCR-ABL1 positive and Chronic myeloid leukemia to investigate apoptosis, autophagy, DNA-damage responses, receptor signaling and trafficking, and drug resistance.

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