Enterobactin synthase
Definition:
EC Tree > 6 Ligases > 6.3 Forming carbon-nitrogen bonds > 6.3.2 Acid—amino-acid ligases (peptide synthases) > 6.3.2.14 enterobactin synthase
Enterobactin synthase is a multienzyme complex converting three molecules each of 2,3-dihydroxybenzoate and L-serine into the siderophore enterobactin. In Escherichia coli it comprises EntB (aryl-carrier protein activated by 4'-phosphopantetheine), EntD (the phosphopantetheinyl transferase that primes EntB), EntE (which ATP-dependently condenses 2,3-dihydroxybenzoate with EntB), EntB's isochorismatase domain and EntF (the NRPS that extends and cyclizes three seryl units). Six ATP are consumed. Structurally it is a NRPS siderophore assembly line.
Enterobactin synthase is a multienzyme complex converting three molecules each of 2,3-dihydroxybenzoate and L-serine into the siderophore enterobactin. In Escherichia coli it comprises EntB (aryl-carrier protein activated by 4'-phosphopantetheine), EntD (the phosphopantetheinyl transferase that primes EntB), EntE (which ATP-dependently condenses 2,3-dihydroxybenzoate with EntB), EntB's isochorismatase domain and EntF (the NRPS that extends and cyclizes three seryl units). Six ATP are consumed. Structurally it is a NRPS siderophore assembly line.
Biomedical Dictionary
The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.
Molarity Calculator
Dilution Calculator
