Envelysin
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.24 Metalloendopeptidases > 3.4.24.12 envelysin
IgA-specific metalloendopeptidase is a 190-kDa zinc metalloprotease found in pathogenic Streptococcus species such as S. sanguis and S. pneumoniae, the type example of peptidase family M26. It cleaves the Pro-/-Thr bond in the hinge region of the human IgA heavy chain, which is distinct from the IgA-specific serine endopeptidase (EC 3.4.21.72). In pathogens it cleaves mucosal IgA to enable immune evasion and colonization. It features a zinc metalloprotease fold secreted into the mucosal niche.
IgA-specific metalloendopeptidase is a 190-kDa zinc metalloprotease found in pathogenic Streptococcus species such as S. sanguis and S. pneumoniae, the type example of peptidase family M26. It cleaves the Pro-/-Thr bond in the hinge region of the human IgA heavy chain, which is distinct from the IgA-specific serine endopeptidase (EC 3.4.21.72). In pathogens it cleaves mucosal IgA to enable immune evasion and colonization. It features a zinc metalloprotease fold secreted into the mucosal niche.
References:
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