FAD-AMP lyase (cyclizing)
Definition:
EC Tree > 4 Lyases > 4.6 Phosphorus-oxygen lyases > 4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date) > 4.6.1.15 FAD-AMP lyase (cyclizing)
FAD-AMP lyase (cyclizing) requires Mn2+ or Co2+. FAD is the best substrate, but the enzyme also splits ribonucleoside-diphosphate-X compounds in which X is an acyclic or cyclic monosaccharide derivative bearing an X-OH group that can attack the proximal phosphorus with the geometry needed to form a P=X product (either a five-atom monocyclic phosphodiester or a cis-bicyclic phosphodiester-pyranose fusion). The reaction is strongly inhibited by ADP or ATP. It converts FAD into AMP and riboflavin cyclic-4',5'-phosphate. Structurally it is a cyclizing FAD lyase.
FAD-AMP lyase (cyclizing) requires Mn2+ or Co2+. FAD is the best substrate, but the enzyme also splits ribonucleoside-diphosphate-X compounds in which X is an acyclic or cyclic monosaccharide derivative bearing an X-OH group that can attack the proximal phosphorus with the geometry needed to form a P=X product (either a five-atom monocyclic phosphodiester or a cis-bicyclic phosphodiester-pyranose fusion). The reaction is strongly inhibited by ADP or ATP. It converts FAD into AMP and riboflavin cyclic-4',5'-phosphate. Structurally it is a cyclizing FAD lyase.
References:
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