Fibrolase
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.24 Metalloendopeptidases > 3.4.24.72 fibrolase
Jararhagin is a hemorrhagic zinc metalloendopeptidase from jararaca snake (Bothrops jararaca) venom, a 52-kDa enzyme containing a disintegrin domain, in peptidase family M12. It hydrolyzes -His10-/-Leu-, -Ala14-/-Leu-, -Tyr16-/-Leu- and -Phe24-/-Phe- bonds in the insulin B chain. In venom it damages basement membranes and inhibits platelet aggregation. It features an M12-family zinc catalytic domain linked to a disintegrin domain.
Jararhagin is a hemorrhagic zinc metalloendopeptidase from jararaca snake (Bothrops jararaca) venom, a 52-kDa enzyme containing a disintegrin domain, in peptidase family M12. It hydrolyzes -His10-/-Leu-, -Ala14-/-Leu-, -Tyr16-/-Leu- and -Phe24-/-Phe- bonds in the insulin B chain. In venom it damages basement membranes and inhibits platelet aggregation. It features an M12-family zinc catalytic domain linked to a disintegrin domain.
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