Formamidase

Definition:

EC Tree > 3 Hydrolases > 3.5 Acting on carbon-nitrogen bonds, other than peptide bonds > 3.5.1 In linear amides > 3.5.1.49 formamidase
Urease is a nickel metalloenzyme found in many bacteria, some archaea, and many eukaryotes including plants, some invertebrates and microbial eukaryotes. It hydrolyzes urea into ammonia and carbamate, which spontaneously hydrolyzes to carbonic acid and a second ammonia; in water the products become ammonium and bicarbonate. Urease was first obtained in 1874, named in 1890, and crystallized in 1926 as the first enzyme shown to be a protein. It hydrolyzes urea with two waters into bicarbonate and two ammonia. In pathogens and soils it releases ammonia. It features a dinickel urease active site.

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