Fragilysin
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.24 Metalloendopeptidases > 3.4.24.74 fragilysin
Lysostaphin is a zinc-dependent 25-kDa endopeptidase from Staphylococcus simulans, the type example of peptidase family M23. It lyses S. aureus cells by acting on the cross-bridges of the cell wall, hydrolyzing the -Gly-/-Gly- bond in the pentaglycine inter-peptide link joining staphylococcal cell-wall peptidoglycans. In the bacterium it kills competing staphylococci. It features an M23-family zinc catalytic fold specialized for the pentaglycine bridge.
Lysostaphin is a zinc-dependent 25-kDa endopeptidase from Staphylococcus simulans, the type example of peptidase family M23. It lyses S. aureus cells by acting on the cross-bridges of the cell wall, hydrolyzing the -Gly-/-Gly- bond in the pentaglycine inter-peptide link joining staphylococcal cell-wall peptidoglycans. In the bacterium it kills competing staphylococci. It features an M23-family zinc catalytic fold specialized for the pentaglycine bridge.
References:
Biomedical Dictionary
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