Fumarate hydratase
Definition:
EC Tree > 4 Lyases > 4.2 Carbon-oxygen lyases > 4.2.1 Hydro-lyases > 4.2.1.2 fumarate hydratase
Fumarate hydratase is a TCA-cycle enzyme that hydrates fumarate into S-malate (or the reverse), interconverting the C4-dicarboxylates. It appears in viruses and cellular organisms and is also a moonlighting tumor-suppressor protein in mitochondria and the cytosol. Structurally it exists as a class I [4Fe-4S] iron-sulfur enzyme and a class II homodimeric non-metal enzyme.
Fumarate hydratase is a TCA-cycle enzyme that hydrates fumarate into S-malate (or the reverse), interconverting the C4-dicarboxylates. It appears in viruses and cellular organisms and is also a moonlighting tumor-suppressor protein in mitochondria and the cytosol. Structurally it exists as a class I [4Fe-4S] iron-sulfur enzyme and a class II homodimeric non-metal enzyme.
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