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Glucuronate isomerase

Definition:

EC Tree > 5 Isomerases > 5.3 Intramolecular oxidoreductases > 5.3.1 Interconverting aldoses and ketoses, and related compounds > 5.3.1.12 glucuronate isomerase
Glucuronate isomerase also converts D-galacturonate to D-tagaturonate. It interconverts D-glucuronate and D-fructuronate in uronate catabolism. It appears in viruses and cellular organisms. Structurally it is a uronate isomerase.

References:

[1]. Williams L., et al. Uronate isomerase: a nonhydrolytic member of the amidohydrolase superfamily with an ambivalent requirement for a divalent metal ion (2006), Biochemistry , 45, 7453-7462.

[2]. Nguyen T.T., et al. The mechanism of the reaction catalyzed by uronate isomerase illustrates how an isomerase may have evolved from a hydrolase within the amidohydrolase superfamily (2009), Biochemistry , 48, 8879-8890.

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