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Glucuronosyltransferase

Definition:

EC Tree > 2 Transferases > 2.4 Glycosyltransferases > 2.4.1 Hexosyltransferases > 2.4.1.17 glucuronosyltransferase
Glucuronosyltransferase (UGT family) conjugates a broad range of phenols, alcohols, amines and fatty acids with UDP-glucuronic acid into β-D-glucuronosides for detoxication and excretion.

References:

[1]. Koster A.S., et al. Kinetic properties of the rat intestinal microsomal 1-naphthol:UDP-glucuronosyl transferase. Inhibition by UDP and UDP-N-acetylglucosamine (1983), Biochim. Biophys. Acta , 761, 76-85.

[2]. Matern H., et al. Isolation and characterization of rat liver microsomal UDP-glucuronosyltransferase activity toward chenodeoxycholic acid and testosterone as a single form of enzyme (1982), J. Biol. Chem. , 257, 7422-7429.

[3]. Li D., et al. Identification of aspartic acid and histidine residues mediating the reaction mechanism and the substrate specificity of the human UDP-glucuronosyltransferases 1A (2007), J. Biol. Chem. , 282, 36514-36524.

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