Grixazone synthase
Definition:
EC Tree > 1 Oxidoreductases > 1.10 Acting on diphenols and related substances as donors > 1.10.3 With oxygen as acceptor > 1.10.3.15 grixazone synthase
Grixazone synthase is a type 3 multi-copper protein isolated from Streptomyces griseus, catalyzing an 8-electron oxidation that requires a copper chaperone (GriE) for activation. Acting on 3-amino-4-hydroxybenzoate together with N-acetyl-L-cysteine, it yields grixazone B (with 4 H2O and CO2), and also acts on 3-amino-4-hydroxybenzaldehyde to give grixazone A, with the second aldehyde group presumably lost as formate.
Grixazone synthase is a type 3 multi-copper protein isolated from Streptomyces griseus, catalyzing an 8-electron oxidation that requires a copper chaperone (GriE) for activation. Acting on 3-amino-4-hydroxybenzoate together with N-acetyl-L-cysteine, it yields grixazone B (with 4 H2O and CO2), and also acts on 3-amino-4-hydroxybenzaldehyde to give grixazone A, with the second aldehyde group presumably lost as formate.
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