Hapalindole U synthase
Definition:
EC Tree > 5 Isomerases > 5.5 Intramolecular lyases > 5.5.1 Intramolecular lyases (only sub-subclass identified to date) > 5.5.1.36 hapalindole U synthase
Hapalindole U synthase requires Ca2+; belonging to the Stig cyclases, it has been characterized from multiple species of the cyanobacterial genera Fischerella and Westiellopsis. Stig cyclases catalyze a three-step process including a Cope rearrangement, 6-exo-trig cyclization and electrophilic aromatic substitution; the enzyme is a heterodimer of two different proteins (AmbU1 and AmbU4), each inactive alone. It cyclizes 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole into hapalindole U. Structurally it is a Stig cyclase.
Hapalindole U synthase requires Ca2+; belonging to the Stig cyclases, it has been characterized from multiple species of the cyanobacterial genera Fischerella and Westiellopsis. Stig cyclases catalyze a three-step process including a Cope rearrangement, 6-exo-trig cyclization and electrophilic aromatic substitution; the enzyme is a heterodimer of two different proteins (AmbU1 and AmbU4), each inactive alone. It cyclizes 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole into hapalindole U. Structurally it is a Stig cyclase.
References:
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