Helper-component proteinase
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.22 Cysteine endopeptidases > 3.4.22.45 helper-component proteinase
Helper-component proteinase is a multifunctional cysteine proteinase known from many potyviruses. The tobacco etch virus HC-Pro has several activities: the N-terminal region is required for aphid transmission and efficient genome amplification, the central region for long-distance movement in plants, and the C-terminal domain has cysteine endopeptidase activity. It hydrolyzes a Gly-/-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-/-Gly, during processing of the potyviral polyprotein. In the virus it autoreleases itself and controls aphid transmission. It features a cysteine-protease C-terminal domain plus RNA-binding and movement regions.
Helper-component proteinase is a multifunctional cysteine proteinase known from many potyviruses. The tobacco etch virus HC-Pro has several activities: the N-terminal region is required for aphid transmission and efficient genome amplification, the central region for long-distance movement in plants, and the C-terminal domain has cysteine endopeptidase activity. It hydrolyzes a Gly-/-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-/-Gly, during processing of the potyviral polyprotein. In the virus it autoreleases itself and controls aphid transmission. It features a cysteine-protease C-terminal domain plus RNA-binding and movement regions.
References:
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