Heparanase
Definition:
EC Tree > 3 Hydrolases > 3.2 Glycosylases > 3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds > 3.2.1.166 heparanase
Heparanase is an endo-beta-D-glucuronidase that cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group, cutting macromolecular heparin into 5000-20000 Da fragments; inside cells it cleaves heparan-sulfate glycosaminoglycans from proteoglycan core proteins and degrades them to small oligosaccharides that are then trafficked to lysosomes for complete breakdown, and when secreted it degrades basement-membrane heparan sulfate at sites of injury or inflammation, enabling immune-cell extravasation into non-vascular spaces and releasing factors that regulate cell proliferation and angiogenesis. It is a key regulator of inflammation, metastasis and angiogenesis. It is distributed across Eukaryota and Bacteria.
Heparanase is an endo-beta-D-glucuronidase that cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group, cutting macromolecular heparin into 5000-20000 Da fragments; inside cells it cleaves heparan-sulfate glycosaminoglycans from proteoglycan core proteins and degrades them to small oligosaccharides that are then trafficked to lysosomes for complete breakdown, and when secreted it degrades basement-membrane heparan sulfate at sites of injury or inflammation, enabling immune-cell extravasation into non-vascular spaces and releasing factors that regulate cell proliferation and angiogenesis. It is a key regulator of inflammation, metastasis and angiogenesis. It is distributed across Eukaryota and Bacteria.
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