Hepsin
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.21 Serine endopeptidases > 3.4.21.106 hepsin
Hepsin is a type-II membrane-associated serine peptidase in family S1A implicated in cell growth and development; it activates blood-coagulation factor VII by cleavage of the Arg152-Ile153 bond in BHK cells, suggesting a role in coagulation initiation, with no cleavage after aromatic or aliphatic residues; occupancy of the S2 site is an absolute requirement, a basic residue at S2 preferred over aliphatic, and Gln at S3 much more favourable than Ala; it cleaves after basic residues, Arg strongly preferred to Lys. By activating factor VII it links cell-surface proteolysis to coagulation.
Hepsin is a type-II membrane-associated serine peptidase in family S1A implicated in cell growth and development; it activates blood-coagulation factor VII by cleavage of the Arg152-Ile153 bond in BHK cells, suggesting a role in coagulation initiation, with no cleavage after aromatic or aliphatic residues; occupancy of the S2 site is an absolute requirement, a basic residue at S2 preferred over aliphatic, and Gln at S3 much more favourable than Ala; it cleaves after basic residues, Arg strongly preferred to Lys. By activating factor VII it links cell-surface proteolysis to coagulation.
References:
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[1]. Herter S., et al. Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers (2005), Biochem. J. , 390, 125-136. [Content Brief]
[2]. Wu Q., et al. Hepsin and prostate cancer (2007), Front. Biosci. , 12, 5052-5059.
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