HtrA2 peptidase
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.21 Serine endopeptidases > 3.4.21.108 HtrA2 peptidase
HtrA2 peptidase (Omi) is a mitochondrial serine peptidase in family S1C up-regulated in mammalian cells by heat-shock and tunicamycin stress; it can induce apoptosis in a caspase-independent manner through its peptidase activity and in a caspase-dependent manner by disrupting the interaction between caspase and inhibitor of apoptosis (IAP); it cleaves non-polar aliphatic P1 residues, preferentially Val, Ile and Met, and at P2/P3 selects Arg most strongly with secondary preference for other hydrophilic residues. By degrading IAPs it promotes programmed cell death. It appears in viruses and cellular organisms.
HtrA2 peptidase (Omi) is a mitochondrial serine peptidase in family S1C up-regulated in mammalian cells by heat-shock and tunicamycin stress; it can induce apoptosis in a caspase-independent manner through its peptidase activity and in a caspase-dependent manner by disrupting the interaction between caspase and inhibitor of apoptosis (IAP); it cleaves non-polar aliphatic P1 residues, preferentially Val, Ile and Met, and at P2/P3 selects Arg most strongly with secondary preference for other hydrophilic residues. By degrading IAPs it promotes programmed cell death. It appears in viruses and cellular organisms.
References:
Biomedical Dictionary
The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.
Molarity Calculator
Dilution Calculator
