Hydroxysqualene synthase
Definition:
EC Tree > 4 Lyases > 4.2 Carbon-oxygen lyases > 4.2.3 Acting on phosphates > 4.2.3.156 hydroxysqualene synthase
Hydroxysqualene synthase is a bacterial enzyme isolated from Rhodopseudomonas palustris and Zymomonas mobilis. Together with EC 2.5.1.103 (presqualene diphosphate synthase) and EC 1.17.8.1 (hydroxysqualene dehydroxylase), it converts all-trans-farnesyl diphosphate into squalene via presqualene diphosphate. In eukaryotes the same conversion is achieved in one step by EC 2.5.1.21 (squalene synthase). With water it converts presqualene diphosphate into hydroxysqualene and diphosphate. Structurally it is a bacterial squalene-biosynthesis cyclase.
Hydroxysqualene synthase is a bacterial enzyme isolated from Rhodopseudomonas palustris and Zymomonas mobilis. Together with EC 2.5.1.103 (presqualene diphosphate synthase) and EC 1.17.8.1 (hydroxysqualene dehydroxylase), it converts all-trans-farnesyl diphosphate into squalene via presqualene diphosphate. In eukaryotes the same conversion is achieved in one step by EC 2.5.1.21 (squalene synthase). With water it converts presqualene diphosphate into hydroxysqualene and diphosphate. Structurally it is a bacterial squalene-biosynthesis cyclase.
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